Publications from the Center 2013 - 2015

2015

Joel M, Mughal AA, Grieg Z, Murrell W, Palmero S, Mikkelsen B, Fjerdingstad HB, Sandberg CJ, Behnan J, Glover JC, Langmoen IA, Stangeland B. Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo. Mol Cancer. 2015 Jun 17;14:121. doi: 10.1186/s12943-015-0398-x.

Kasumacic N, Lambert FM, Coulon P, Bras H, Vinay L, Perreault MC, Glover JC. Segmental organization of vestibulospinal inputs to spinal interneurons mediating crossed activation of thoracolumbar motoneurons in the neonatal mouse. J Neurosci. 2015 May 27;35(21):8158-69. doi: 10.1523/JNEUROSCI.5188-14.2015.       

 Blacklaws J, Deska-Gauthier D, Jones CT, Petracca YL, Liu M, Zhang H, Fawcett JP, Glover JC, Lanuza GM, Zhang Y. Sim1 is required for the migration and axonal projections of V3 interneurons in the developing mouse spinal cord. Dev Neurobiol. 2015 Sep;75(9):1003-17. doi: 10.1002/dneu.22266. Epub 2015 Feb 18.

Rønningen T, Shah A, Oldenburg A, Vekterud K, Delbarre E, Moskaug JØ, Collas P. Pre-patterning of differentiation-driven nuclear lamin A/C-associated chromatin domains by GlcNAcylated histone H2B. Genome Res. 2015 Sep 10. pii: gr.193748.115. [Epub ahead of print]

Taghdouini AE, Sørensen AL, Reiner AH, Coll M, Verhulst S, Mannaerts I, Øie CI, Smedsrød B, Najimi M, Sokal E, Luttun A, Sancho-Bru P, Collas P, van Grunsven LA. Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells. Oncotarget. 2015 Aug 31. [Epub ahead of print]

Udugama M, Chang FT, Chan FL, Tang MC, Pickett HA, McGhie JD, Mayne L, Collas P, Mann JR, Wong LH. Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres. Nucleic Acids Res. 2015 Aug 24. pii: gkv847. [Epub ahead of print]

Paulsen J, Gramstad O, Collas P. Manifold Based Optimization for Single-Cell 3D Genome Reconstruction. PLoS Comput Biol. 2015 Aug 11;11(8):e1004396. doi: 10.1371/journal.pcbi.1004396. eCollection 2015 Aug.

Lund EG, Collas P, Delbarre E. Transcription outcome of promoters enriched in histone variant H3.3 defined by positioning of H3.3 and local chromatin marks. Biochem Biophys Res Commun. 2015 May 1;460(2):348-53. doi: 10.1016/j.bbrc.2015.03.037. Epub 2015 Mar 14.

Chang FT, Chan FL, R McGhie JD, Udugama M, Mayne L, Collas P, Mann JR, Wong LH. CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells. Nucleic Acids Res. 2015 Mar 11;43(5):2603-14. doi: 10.1093/nar/gkv104. Epub 2015 Feb 17.

Lund EG, Duband-Goulet I, Oldenburg A, Buendia B, Collas P. Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin. Nucleus. 2015;6(1):30-9. doi: 10.4161/19491034.2014.990855.

Pullisaar H, Verket A, Szoke K, Tiainen H, Haugen HJ, Brinchmann JE, Reseland JE, Østrup E. Alginate hydrogel enriched with enamel matrix derivative to target osteogenic cell differentiation in TiO2 scaffolds. J Tissue Eng. 2015 Mar 12;6:2041731415575870. doi: 10.1177/2041731415575870. eCollection 2015.

Hart ML, Izeta A, Herrera-Imbroda B, Amend B, Brinchmann JE. Cell Therapy for Stress Urinary Incontinence. Tissue Eng Part B Rev. 2015 Aug;21(4):365-76. doi: 10.1089/ten.TEB.2014.0627. Epub 2015 Apr 22. 

Stangeland B, Mughal AA, Grieg Z, Sandberg CJ, Joel M, Nygård S, Meling T, Murrell W, Vik Mo EO, Langmoen IA. Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells. Oncotarget. 2015 Jul 20. [Epub ahead of print] 

Mughal AA, Grieg Z, Skjellegrind H, Fayzullin A, Lamkhannat M, Joel M, Ahmed MS, Murrell W, Vik-Mo EO, Langmoen IA, Stangeland B. Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells. Mol Cancer. 2015 Aug 21;14(1):160. doi: 10.1186/s12943-015-0432-z. 

Halvorsen CM, Rønning P, Hald J, Johannesen TB, Kolstad F, Langmoen IA, Lied B, Skaar Holme S, Helseth E. The Long-term Outcome After Resection of Intraspinal Nerve Sheath Tumors: Report of 131 Consecutive Cases. Neurosurgery. 2015 Jul 4. [Epub ahead of print]

Rustad EH, Dai HY, Hov H, Coward E, Beisvag V, Myklebost O, Hovig E, Nakken S, Vodák D, Meza-Zepeda LA, Sandvik AK, Wader KF, Misund K, Sundan A, Aarset H, Waage A. BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis. Blood Cancer J. 2015 Mar 20;5:e299. doi: 10.1038/bcj.2015.24. 

Serguienko A, Grad I, Wennerstrøm AB, Meza-Zepeda LA, Thiede B, Stratford EW, Myklebost O, Munthe E. Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA. Oncotarget. 2015 Feb 10;6(4):2451-65. 

Naderi EH, Skah S, Ugland H, Myklebost O, Sandnes DL, Torgersen ML, Josefsen D, Ruud E, Naderi S, Blomhoff HK. Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death. Mol Cancer. 2015 Jan 27;14:14. doi: 10.1186/s12943-014-0278-9. 

Roald AB, Aass HC, Moe MC. Recovery of plasma vascular endothelial growth factor concentrations during aflibercept loading phase and after the transition to bimonthly treatment for neovascular age-related macular degeneration. Br J Ophthalmol. 2015 May 12. pii: bjophthalmol-2015-306781. doi: 10.1136/bjophthalmol-2015-306781. [Epub ahead of print] 

Salvanos P, Utheim TP, Moe MC, Eide N, Bragadόttir R. Autofluorescence imaging in the differential diagnosis of optic disc melanocytoma. Acta Ophthalmol. 2015 Aug;93(5):476-80. doi: 10.1111/aos.12725. Epub 2015 Apr 28. 

Lumi X, Hawlina M, Glavač D, Facskó A, Moe MC, Kaarniranta K, Petrovski G. Ageing of the vitreous: From acute onset floaters and flashes to retinal detachment. Ageing Res Rev. 2015 May;21:71-7. doi: 10.1016/j.arr.2015.03.006. Epub 2015 Apr 2. Review. 

Jørstad ØK, Faber RT, Moe MC. Initial improvements when converting eyes with treatment-resistant exudative AMD to aflibercept are substantially diminished after increasing treatment intervals from 4 to 8 weeks. Acta Ophthalmol. 2015 Feb 23. doi: 10.1111/aos.12681. [Epub ahead of print] No abstract available.  

Indrevær RL, Moskaug JØ, Paur I, Bøhn SK, Jørgensen SF, Blomhoff R, Aukrust P, Fevang B, Blomhoff HK. IRF4 Is a Critical Gene in Retinoic Acid-Mediated Plasma Cell Formation and Is Deregulated in Common Variable Immunodeficiency-Derived B Cells. J Immunol. 2015 Sep 15;195(6):2601-11. doi: 10.4049/jimmunol.1500250. Epub 2015 Aug 14. 

Eriksen AB, Torgersen ML, Holm KL, Abrahamsen G, Spurkland A, Moskaug JØ, Simonsen A, Blomhoff HK. Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy. Autophagy. 2015;11(3):460-71. doi: 10.1080/15548627.2015.1009797. 

Ougland R, Rognes T, Klungland A, Larsen E. Non-homologous functions of the AlkB homologs. J Mol Cell Biol. 2015 May 23. pii: mjv029. [Epub ahead of print] Review. 

Chymkowitch P, Nguéa AP, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM. Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes. Genome Res. 2015 Jun;25(6):897-906. doi: 10.1101/gr.185793.114. Epub 2015 Mar 23. 

Seeberg TM, Austad HO, Clausen I, Cederkvist H, Bjørås M, Johansen RF. An in vitro Study of Protein Adsorption to Biocompatible Coatings. Stud Health Technol Inform. 2015;211:166-71. 

Dalhus B, Alseth I, Bjørås M. Structural basis for incision at deaminated adenines in DNA and RNA by endonuclease V. Prog Biophys Mol Biol. 2015 Mar;117(2-3):134-42. doi: 10.1016/j.pbiomolbio.2015.03.005. Epub 2015 Mar 28. Review. 

Bliksøen M, Baysa A, Eide L, Bjørås M, Suganthan R, Vaage J, Stensløkken KO, Valen G. Mitochondrial DNA damage and repair during ischemia-reperfusion injury of the heart. J Mol Cell Cardiol. 2015 Jan;78:9-22. doi: 10.1016/j.yjmcc.2014.11.010. Epub 2014 Nov 18. 

Almåsbak H, Walseng E, Kristian A, Myhre MR, Suso EM, Munthe LA, Andersen JT, Wang MY, Kvalheim G, Gaudernack G, Kyte JA. Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model. Gene Ther. 2015 May;22(5):391-403. doi: 10.1038/gt.2015.4. Epub 2015 Feb 5. 

Eide N, Faye RS, Høifødt HK, Sandstad B, Qvale G, Faber R, Jebsen P, Kvalheim G, Fodstad Ø. Immunomagnetic detection of micrometastatic cells in bone marrow of uveal melanoma patients: a paradox. Acta Ophthalmol. 2015 Feb;93(1):59-66. doi: 10.1111/aos.12462.

 

2014

Sivertsen MS, Glover JC, Perreault MC (2014)
Organization of pontine reticulospinal inputs to motoneurons controlling axial and limb muscles in the neonatal mouse.
J Neurophysiol. 2014 Jun 18. pii: jn.00820.2013. [Epub ahead of print]

Straka H, Fritzsch B, Glover JC. (2014)
Connecting ears to eye muscles: evolution of a 'simple' reflex arc.
Brain Behav Evol. 2014;83(2):162-75.

Bjørnstad S, Paulsen RE, Erichsen A, Glover JC, Roald B. (2014)
Type I and II pneumocyte differentiation in the developing fetal chicken lung: conservation of pivotal proteins from birds to human in the struggle for life at birth.
Neonatology. 2014;105(2):112-20.

Glover JC (2014) 
Conjugate dextran amines as intracellular tracers for visualizing and manipulating neurons. (2014) In: Dextran: Chemical Structure, Applications and Potential Side Effects. Recent Trends in Biotechnology.
Ed: Garrett P. Figgs. Nova Publishers, ISBN: 978-1-62948-960-5.

Østrup O, Reiner AH, Aleström P, Collas P. (2014)
The specific alteration of histone methylation profiles by DZNep during early zebrafish development.
Biochim Biophys Acta. 2014 Sep 28;1839(11):1307-1315. doi: 10.1016/j.bbagrm.2014.09.013. [Epub ahead of print]

Reppe S, Noer A, Grimholt RM, Halldórsson BV, Medina-Gomez C, Gautvik VT, Olstad OK, Berg JP, Datta H, Estrada K, Hofman A, Uitterlinden AG, Rivadeneira F, Lyle R, Collas P, Gautvik KM. (2014)
Methylation of bone SOST, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women.
J Bone Miner Res. 2014 Aug 22. doi: 10.1002/jbmr.2342. [Epub ahead of print]

Ivanauskiene K, Delbarre E, McGhie JD, Küntziger T, Wong LH, Collas P. (2014)
The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity.
 
Genome Res. 2014 Jul 21. pii: gr.173831.114. [Epub ahead of print]

Carrière A, Jeanson Y, Berger-Müller S, André M, Chenouard V, Arnaud E, Barreau C, Walther R, Galinier A, Wdziekonski B, Villageois P, Louche K, Collas P, Moro C, Dani C, Villarroya F, Casteilla L. (2014)
Browning of White Adipose Cells by Intermediate Metabolites:An Adaptive Mechanism to Alleviate Redox Pressure.
Diabetes. 2014 May 1. [Epub ahead of print]

Lund E, Oldenburg AR, Collas P. (2014)
Enriched domain detector: a program for detection of wide genomic enrichment domains robust against local variations.
Nucleic Acids Res. 2014;42(11):e92. doi: 10.1093/nar/gku324. Epub 2014 Apr 29.

Aanes H, Winata C, Moen LF, Østrup O, Mathavan S, Collas P, Rognes T, Aleström P. (2014)
Normalization of RNA-sequencing data from samples with varying mRNA levels.
PLoS One. 2014 Feb 25;9(2):e89158. doi: 10.1371/journal.pone.0089158. eCollection 2014.

Aanes H, Collas P, Aleström P. (2014)
Transcriptome dynamics and diversity in the early zebrafish embryo.
Brief Funct Genomics. 2014 Mar;13(2):95-105. doi: 10.1093/bfgp/elt049. Epub 2013 Dec 12.

Collas P, Lund EG, Oldenburg AR. (2014)
Closing the (nuclear) envelope on the genome: how nuclear lamins interact with promoters and modulate gene expression.
Bioessays. 2014 Jan;36(1):75-83. doi: 10.1002/bies.201300138. Epub 2013 Nov 24.

Shah, A., Oldenburg, A.R., Collas, P. (2014)
A hyper-dynamic nature of bivalent promoter states underlies coordinated developmental gene expression modules. BMC Genomics 15, 1186.

Vadrot N, Duband-Goulet I, Cabet E, Attanda W, Barateau A, Vicart P, Gerbal F, Briand N, Vigouroux C, Oldenburg AR, Lund EG, Collas P, Buendia B. (2014)
The p.R482W substitution in A-type lamins deregulates SREBP1 activity in Dunnigan-type familial partial lipodystrophy
. Hum. Mol. Genet. PMID: 25524705.

Jakobsen RB, Østrup E, Zhang X, Mikkelsen TS, Brinchmann JE. (2014)
Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling
PLoS One. 2014 May 9;9(5):e96615. doi: 10.1371/journal.pone.0096615. eCollection 2014. PMID: 24816923 [PubMed - in process]

Pullisaar H, Reseland JE, Haugen HJ, Brinchmann JE, Østrup E. (2014)
Simvastatin coating of TiO₂ scaffold induces osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells.
Biochem Biophys Res Commun. 2014 Apr 25;447(1):139-44. doi: 10.1016/j.bbrc.2014.03.133. Epub 2014 Apr 2.

Olderøy MØ, Lilledahl MB, Beckwith MS, Melvik JE, Reinholt F, Sikorski P, Brinchmann JE. (2014)
Biochemical and structural characterization of neocartilage formed by mesenchymal stem cells in alginate hydrogels.
PLoS One. 2014 Mar 13;9(3):e91662. doi: 10.1371/journal.pone.0091662. eCollection 2014.

Herlofsen SR, Høiby T, Cacchiarelli D, Zhang X, Mikkelsen TS, Brinchmann JE. (2014)
Brief report: importance of SOX8 for in vitro chondrogenic differentiation of human mesenchymal stromal cells.
Stem Cells. 2014 Jun;32(6):1629-35. doi: 10.1002/stem.1642.

Karlsen TA, Jakobsen RB, Mikkelsen TS, Brinchmann JE. (2014)
microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN.
Stem Cells Dev. 2014 Feb 1;23(3):290-304. doi: 10.1089/scd.2013.0209. Epub 2013 Nov 7

Behnan J, Isakson P, Joel M, Cilio C, Langmoen IA, Vik-Mo EO, Badn W. (2014)
Recruited brain tumor-derived mesenchymal stem cells contribute to brain tumor progression.
Stem Cells. 2014 May;32(5):1110-23. doi: 10.1002/stem.1614.

Sandberg CJ, Vik-Mo EO, Behnan J, Helseth E, Langmoen IA. (2014)
Transcriptional profiling of adult neural stem-like cells from the human brain.
PLoS One. 2014 Dec 16;9(12):e114739.

Berg-Johnsen J, Helseth E, Langmoen IA. (2014)
Cerebral revascularization for skull base tumors.
World Neurosurg. 2014 Nov;82(5):575-6.

Garsed DW, Marshall OJ, Corbin VD, Hsu A, Di Stefano L, Schröder J, Li J, Feng ZP, Kim BW, Kowarsky M, Lansdell B, Brookwell R, Myklebost O, Meza-Zepeda L, Holloway AJ, Pedeutour F, Choo KH, Damore MA, Deans AJ, Papenfuss AT, Thomas DM. (2014) The architecture and evolution of cancer neochromosomes.
Cancer Cell. 2014 Nov 10;26(5):653-67

Wennerström AB, Lothe IM, Sandhu V, Kure EH, Myklebost O, Munthe E. (2014)
Generation and characterisation of novel pancreatic adenocarcinoma xenograft models and corresponding primary cell lines.

PLoS One. 2014 Aug 22;9(8):e103873. doi: 10.1371/journal.pone.0103873. eCollection 2014.

Chilamakuri CS, Lorenz S, Madoui MA, Vodák D, Sun J, Hovig E, Myklebost O, Meza-Zepeda LA.(2014)
Performance comparison of four exome capture systems for deep sequencing.
BMC Genomics. 2014 Jun 9;15:449. doi: 10.1186/1471-2164-15-449.

Håkelien AM, Bryne JC, Harstad KG, Lorenz S, Paulsen J, Sun J, Mikkelsen TS, Myklebost O, Meza-Zepeda LA. (2014)
The regulatory landscape of osteogenic differentiation.
Stem Cells. 2014 Oct;32(10):2780-93. doi: 10.1002/stem.1759.

Barøy T, Kresse SH, Skårn M, Stabell M, Castro R, Lauvrak S, Llombart-Bosch A, Myklebost O, Meza-Zepeda LA. (2014)
Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model.
Mol Cancer. 2014 Apr 28;13:93. doi: 10.1186/1476-4598-13-93.

Skårn M, Noordhuis P, Wang MY, Veuger M, Kresse SH, Egeland EV, Micci F, Namløs HM, Håkelien AM, Olafsrud SM, Lorenz S, Haraldsen G, Kvalheim G, Meza-Zepeda LA, Myklebost O. (2014)
Generation and characterization of an immortalized human mesenchymal stromal cell line.
Stem Cells Dev. 2014 Oct 1;23(19):2377-89. doi: 10.1089/scd.2013.0599. Epub 2014 Jun 30.

Stratford EW, Daffinrud J, Munthe E, Castro R, Waaler J, Krauss S, Myklebost O. (2014)
The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines.
Cancer Med. 2014 Feb;3(1):36-46. doi: 10.1002/cam4.170. Epub 2013 Dec 17.

Petrovski G, Pasztor K, Orosz L, Albert R, Mencel E, Moe MC, Kaarniranta K, Facsko A, Megyeri K. (2014)
Herpes simplex virus types 1 and 2 modulate autophagy in SIRC corneal cells.
J Biosci. 2014 Sep;39(4):683-92.

Andjelić S, Lumi X, Yan X, Graw J, Moe MC, Facskó A, Hawlina M, Petrovski G. (2014)
Characterization of ex vivo cultured neuronal- and glial- like cells from human idiopathic epiretinal membranes.
BMC Ophthalmol. 2014 Dec 23;14:165.

Preda MB, Rønningen T, Burlacu A, Simionescu M, Moskaug JØ, Valen G. (2014)
Remote transplantation of mesenchymal stem cells protects the heart against ischemia-reperfusion injury.

Stem Cells. 2014 Aug;32(8):2123-34. doi: 10.1002/stem.1687.

Robertson AB, Robertson J, Fusser M, Klungland A. (2014)
Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination.

Nucleic Acids Res. 2014 Dec 1;42(21):13280-93

Dahl JA, Klungland A. (2014)
Micro Chromatin Immunoprecipitation (μChIP) from Early Mammalian Embryos.
Methods Mol Biol. 2015;1222:227-45. doi: 10.1007/978-1-4939-1594-1_17.

Nilsen A, Fusser M, Greggains G, Fedorcsak P, Klungland A. (2014)
ALKBH4 depletion in mice leads to spermatogenic defects.
PLoS One. 2014 Aug 25;9(8):e105113. doi: 10.1371/journal.pone.0105113. eCollection 2014.

Klungland A, Dahl JA. (2014)
Dynamic RNA modifications in disease.
Curr Opin Genet Dev. 2014 Jul 5;26C:47-52. doi: 10.1016/j.gde.2014.05.006. [Epub ahead of print] Review.

Robertson AB, Dahl JA, Klungland A. (2014)
DNA metabolism: bases of DNA repair and regulation.
Nat Chem Biol. 2014 Jul;10(7):487-8. doi: 10.1038/nchembio.1553.

Zdżalik D, Vågbø CB, Kirpekar F, Davydova E, Puścian A, Maciejewska AM, Krokan HE, Klungland A, Tudek B, van den Born E, Falnes PØ. (2014)
Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.
PLoS One. 2014 Jun 10;9(6):e98729. doi: 10.1371/journal.pone.0098729. eCollection 2014

Yang M, Luna L, Sørbø JG, Alseth I, Johansen RF, Backe PH, Danbolt NC, Eide L, Bjørås M. (2014)
Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21.
Free Radic Biol Med. 2014 Sep 16;77C:41-48. doi: 10.1016/j.freeradbiomed.2014.09.003. [Epub ahead of print]

Alseth I, Dalhus B, Bjørås M. (2014)
Inosine in DNA and RNA.
Curr Opin Genet Dev. 2014 Aug 28;26C:116-123. doi: 10.1016/j.gde.2014.07.008. [Epub ahead of print] Review.

Stray-Pedersen A, Backe PH, Sorte HS, Mørkrid L, Chokshi NY, Erichsen HC, Gambin T, Elgstøen KB, Bjørås M, Wlodarski MW, Krüger M, Jhangiani SN, Muzny DM, Patel A, Raymond KM, Sasa GS, Krance RA, Martinez CA, Abraham SM, Speckmann C, Ehl S, Hall P, Forbes LR, Merckoll E, Westvik J, Nishimura G, Rustad CF, Abrahamsen TG, Rønnestad A, Osnes LT, Egeland T, Rødningen OK, Beck CR; Baylor-Johns Hopkins Center for Mendelian Genomics, Boerwinkle EA, Gibbs RA, Lupski JR, Orange JS, Lausch E, Hanson IC. (2014)
PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia.
Am J Hum Genet. 2014 Jul 3;95(1):96-107. doi: 10.1016/j.ajhg.2014.05.007. Epub 2014 Jun 12.

Strand JM, Skinnes R, Scheffler K, Rootvelt T, Woldseth B, Bjørås M, Eide L. (2014)
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis.
Metabolism. 2014 Aug;63(8):1063-70. doi: 10.1016/j.metabol.2014.05.003. Epub 2014 May 9.

Wang W, Scheffler K, Esbensen Y, Strand JM, Stewart JB, Bjørås M, Eide L. (2014)
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.
PLoS One. 2014 May 12;9(5):e96940. doi: 10.1371/journal.pone.0096940. eCollection 2014.

Sand KM, Dalhus B, Christianson GJ, Bern M, Foss S, Cameron J, Sleep D, Bjørås M, Roopenian DC, Sandlie I, Andersen JT. (2014)
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies.
J Biol Chem. 2014 Jun 13;289(24):17228-39. doi: 10.1074/jbc.M113.522565. Epub 2014 Apr 24.

Strand JM, Scheffler K, Bjørås M, Eide L. (2014)
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences.
DNA Repair (Amst). 2014 Jun;18:44-51. doi: 10.1016/j.dnarep.2014.03.003. Epub 2014 Mar 27.

Andersen JT, Dalhus B, Viuff D, Ravn BT, Gunnarsen KS, Plumridge A, Bunting K, Antunes F, Williamson R, Athwal S, Allan E, Evans L, Bjørås M, Kjærulff S, Sleep D, Sandlie I, Cameron J. (2014)
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.
J Biol Chem. 2014 May 9;289(19):13492-502. doi: 10.1074/jbc.M114.549832. Epub 2014 Mar 20.

Aamann MD, Hvitby C, Popuri V, Muftuoglu M, Lemminger L, Skeby CK, Keijzers G, Ahn B, Bjørås M, Bohr VA, Stevnsner T. (2014)
Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity.
Mech Ageing Dev. 2014 Jan;135:1-14. doi: 10.1016/j.mad.2013.12.008. Epub 2014 Jan 7.

Kolstad A, Kumari S, Walczak M, Madsbu U, Hagtvedt T, Bogsrud TV, Kvalheim G, Holte H, Aurlien E, Delabie J, Tierens A, Olweus J. (2014)
Sequential intranodal immunotherapy induces anti-tumor immunity and correlated regression of disseminated follicular lymphoma.
Blood. 2014 Oct 7. pii: blood-2014-07-592162. [Epub ahead of print]

Subklewe M, Geiger C, Lichtenegger FS, Javorovic M, Kvalheim G, Schendel DJ, Bigalke I. (2014)
New generation dendritic cell vaccine for immunotherapy of acute myeloid leukemia.
Cancer Immunol Immunother. 2014 Oct;63(10):1093-103. doi: 10.1007/s00262-014-1600-5. Epub 2014 Sep 4.

Husøy MA, Brinch L, Tjønnfjord GE, Gedde-Dahl D Y T, Heldal D, Holme PA, Dybedal I, Kolstad A, Akkök CA, Rollag H, Gaustad P, Bergan S, Egeland T, Josefsen D, Kvalheim G, Fløisand Y. (2014)
[Allogeneic stem-cell transplantation in adults 1985 - 2012: Results and development].
Tidsskr Nor Laegeforen. 2014 Sep 2;134(16):1569-75. doi: 10.4045/tidsskr.13.1415. eCollection 2014 Sep. Norwegian.

Skårn M, Noordhuis P, Wang MY, Veuger M, Kresse SH, Egeland EV, Micci F, Namløs HM, Håkelien AM, Olafsrud SM, Lorenz S, Haraldsen G, Kvalheim G, Meza-Zepeda LA, Myklebost O. (2014)
Generation and characterization of an immortalized human mesenchymal stromal cell line.
Stem Cells Dev. 2014 Oct 1;23(19):2377-89. doi: 10.1089/scd.2013.0599. Epub 2014 Jun 30.

Woll PS, Kjällquist U, Chowdhury O, Doolittle H, Wedge DC, Thongjuea S, Erlandsson R, Ngara M, Anderson K, Deng Q, Mead AJ, Stenson L, Giustacchini A, Duarte S, Giannoulatou E, Taylor S, Karimi M, Scharenberg C, Mortera-Blanco T, Macaulay IC, Clark SA, Dybedal I, Josefsen D, Fenaux P, Hokland P, Holm MS, Cazzola M, Malcovati L, Tauro S, Bowen D, Boultwood J, Pellagatti A, Pimanda JE, Unnikrishnan A, Vyas P, Göhring G, Schlegelberger B, Tobiasson M, Kvalheim G, Constantinescu SN, Nerlov C, Nilsson L, Campbell PJ, Sandberg R, Papaemmanuil E, Hellström-Lindberg E, Linnarsson S, Jacobsen SE. (2014)
Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.
Cancer Cell. 2014 Jun 16;25(6):794-808. doi: 10.1016/j.ccr.2014.03.036. Epub 2014 May 15. Erratum in: Cancer Cell. 2014 Jun 16;25(6):861.

 

2013

Skårn M, Barøy T, Stratford EW, Myklebost O. (2013) 
Epigenetic Regulation and Functional Characterization of MicroRNA-142 in Mesenchymal Cells. 
PLoS One. 2013 Nov 13;8(11):e79231. 

Karlsen TA, Jakobsen RB, Mikkelsen TS, Brinchmann JE.
microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN.
Stem Cells Dev. 2013 Nov 7. [Epub ahead of print] 

Dajani R, Koo SE, Sullivan GJ, Park IH (2013) 
Investigation of Rett syndrome using pluripotent stem cells. 
J Cell Biochem. 2013 Nov;114(11):2446-53. 

Smeland KB, Kiserud CE, Lauritzsen GF, Fosså A, Hammerstrøm J, Jetne V, Kolstad A, Kvalheim G, Loge JH, Løkeland T, Tangen JM, Holte H, Kvaløy S (2013)
High-dose therapy with autologous stem cell support for lymphoma - from experimental to standard treatment.
Tidsskr Nor Laegeforen. 2013 Sep 3;133(16):1735-1739. 

Vik-Mo EO, Nyakas M, Mikkelsen BV, Moe MC, Due-Tønnesen P, Suso EM, Sæbøe-Larssen S, Sandberg C, Brinchmann JE, Helseth E, Rasmussen AM, Lote K, Aamdal S, Gaudernack G, Kvalheim G, Langmoen IA (2013) Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma. 
Cancer Immunol Immunother. 2013 Sep;62(9):1499-509. Epub 2013 Jul 2. 

Boulland JL, Lambert FM, Züchner M, Ström S, Glover JC (2013)
A neonatal mouse spinal cord injury model for assessing post-injury adaptive plasticity and human stem cell integration. 
PLoS One. 2013 Aug 19;8(8):e71701. 

Sandberg CJ, Altschuler G, Jeong J, Strømme KK, Stangeland B, Murrell W, Grasmo-Wendler UH, Myklebost O, Helseth E, Vik-Mo EO, Hide W, Langmoen IA (2013)
Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome. 
Exp Cell Res. 2013 Aug 15;319(14):2230-43. Epub 2013 Jun 18. 

Wang P, Suo Z, Wang M, Høifødt HK, Fodstad O, Gaudernack G, Kvalheim G (2013) 
In vitro and in vivo properties of CD133 expressing cells from human lung cancer cell lines. 
Exp Hematol Oncol. 2013 Jun 6;2(1):16. 

Hemmingsen M, Vedel S, Skafte-Pedersen P, Sabourin D, Collas P, Bruus H, Dufva M (2013) 
The Role of Paracrine and Autocrine Signaling in the Early Phase of Adipogenic Differentiation of Adipose-derived Stem Cells
PLoS One. 2013 May 28;8(5):e63638. 

Kaur K, Mirlashari MR, Kvalheim G, Kjeldsen-Kragh J (2013) 
3',4'-Dimethoxyflavone and valproic acid promotes the proliferation of human hematopoietic stem cells. 
Stem Cell Res Ther. 2013 May 24;4(3):60. 

Kuijjer ML, Peterse EF, van den Akker BE, Briaire-de Bruijn IH, Serra M, Meza-Zepeda LA, Myklebost O, Hassan AB, Hogendoorn PC, Cleton-Jansen AM (2013) 
IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma. BMC Cancer
2013 May 20;13:245. 

Aanes H, Ostrup O, Andersen IS, Moen LF, Mathavan S, Collas P, Alestrom P (2013) 
Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish. 
BMC Genomics. 2013 May 15;14(1):331. 

Li MM, Nilsen A, Shi Y, Fusser M, Ding YH, Fu Y, Liu B, Niu Y, Wu YS, Huang CM, Olofsson M, Jin KX, Lv Y, Xu XZ, He C, Dong MQ, Rendtlew Danielsen JM, Klungland A, Yang YG (2013) 
ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. 
Nat Commun. 2013;4:1832. 

Fernandes AM, Herlofsen SR, Karlsen TA, Küchler AM, Fløisand Y, Brinchmann JE (2013) 
Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilage
PLoS One. 2013 May 9;8(5):e62994. 

Stratford EW, Bostad M, Castro R, Skarpen E, Berg K, Høgset A, Myklebost O, Selbo PK (2013) Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. 
Biochim Biophys Acta. 2013 Aug;1830(8):4235-43. doi: 10.1016/j.bbagen.2013.04.033. Epub 2013 May 2. 

Østrup O, Olbricht G, Østrup E, Hyttel P, Collas P, Cabot R (2013) 
RNA profiles of porcine embryos during genome activation reveal complex metabolic switch sensitive to in vitro conditions. 
PLoS One. 2013 Apr 29;8(4):e61547. doi: 10.1371/journal.pone.0061547. Print 2013. 

Liu Y, Wu X, Li X, Kvalheim G, Axcrona U, Axcrona K, Suo Z (2013) 
Blocking mtDNA Replication Upregulates the Expression of Stemness-related Genes in Prostate Cancer Cell Lines. 
Ultrastruct Pathol. 2013 May 1. 

Furu K, Klungland A (2013) 
Tzfp represses the androgen receptor in mouse testis. 
PLoS One. 2013 Apr 25;8(4):e62314. doi: 10.1371/journal.pone.0062314. Print 2013. 

Backe PH, Simm R, Laerdahl JK, Dalhus B, Fagerlund A, Okstad OA, Rognes T, Alseth I, Kolstø AB, Bjørås M (2013) 
A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures. 
J Struct Biol. 2013 Apr 25. doi:pii: S1047-8477(13)00107-X. 10.1016/j.jsb.2013.04.007. 

Sioud M, Sæbøe-Larssen S, Hetland TE, Kærn J, Mobergslien A, Kvalheim G (2013) 
Silencing of indoleamine 2,3-dioxygenase enhances dendritic cell immunogenicity and antitumour immunity in cancer patients. Int J Oncol. 2013 Jul;43(1):280-8. doi: 10.3892/ijo.2013.1922. Epub 2013 Apr 25. 

Zheng G, Dahl JA, Niu Y, Fu Y, Klungland A, Yang YG, He C (2013) 
Sprouts of RNA epigenetics: The discovery of mammalian RNA demethylases. 
RNA Biol. 2013 Apr 17;10(6). 

Andersen IS, Lindeman LC, Reiner AH, Østrup O, Aanes H, Aleström P, Collas P (2013) 
Epigenetic marking of the zebrafish developmental program. 
Curr Top Dev Biol. 2013;104:85-112. doi: 10.1016/B978-0-12-416027-9.00003-6. 

Solberg A, Robertson AB, Aronsen JM, Rognmo O, Sjaastad I, Wisløff U, Klungland A (2013) 
Deletion of mouse Alkbh7 leads to obesity. 
J Mol Cell Biol. 2013 Jun;5(3):194-203. doi: 10.1093/jmcb/mjt012. Epub 2013 Apr 8. 

Karlsen TA, Brinchmann JE (2013) 
Liposome Delivery of MicroRNA-145 to Mesenchymal Stem Cells Leads to Immunological Off-target Effects Mediated by RIG-I. Mol Ther. 2013 Jun;21(6):1169-81. doi: 10.1038/mt.2013.55. Epub 2013 Apr 9. 

Bianchini L, Birtwisle L, Saâda E, Bazin A, Long E, Roussel JF, Michiels JF, Forest F, Dani C, Myklebost O, Birtwisle-Peyrottes I, Pedeutour F (2013) 
Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas.Genes Chromosomes Cancer. 2013 Jun;52(6):580-90. doi: 10.1002/gcc.22055. Epub 2013 Mar 18. 

Wang P, Gao Q, Suo Z, Munthe E, Solberg S, Ma L, Wang M, Westerdaal NA, Kvalheim G, Gaudernack G (2013) 
Identification and characterization of cells with cancer stem cell properties in human primary lung cancer cell lines. PLoS One. 2013;8(3):e57020. doi: 10.1371/journal.pone.0057020. Epub 2013 Mar 4. 

Siller R, Greenhough S, Park IH, Sullivan GJ (2013) 
Modelling human disease with pluripotent stem cells. 
Curr Gene Ther. 2013 Apr;13(2):99-110. 

Herlofsen SR, Bryne JC, Høiby T, Wang L, Issner R, Zhang X, Coyne MJ, Boyle P, Gu H, Meza-Zepeda LA, Collas P, Mikkelsen TS, Brinchmann JE (2013) 
Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells. BMC Genomics. 2013 Feb 15;14:105. doi: 10.1186/1471-2164-14-105. 

Weel-Sneve R, Kristiansen KI, Odsbu I, Dalhus B, Booth J, Rognes T, Skarstad K, Bjørås M (2013) 
Single transmembrane peptide DinQ modulates membrane-dependent activities. 
PLoS Genet. 2013;9(2):e1003260. doi: 10.1371/journal.pgen.1003260. Epub 2013 Feb 7. 

Herrmann D, Dahl JA, Lucas-Hahn A, Collas P, Niemann H (2013) 
Histone modifications and mRNA expression in the inner cell mass and trophectoderm of bovine blastocysts. Epigenetics. 2013 Mar;8(3):281-9. doi: 10.4161/epi.23899. Epub 2013 Feb 13. 

Doorn J, Fernandes HA, Le BQ, van de Peppel J, van Leeuwen JP, De Vries MR, Aref Z, Quax PH, Myklebost O, Saris DB, van Blitterswijk CA, de Boer J (2013) 
A small molecule approach to engineering vascularized tissue. 
Biomaterials. 2013 Apr;34(12):3053-63. doi: 10.1016/j.biomaterials.2012.12.037. Epub 2013 Jan 29. 

Rolseth V, Krokeide SZ, Kunke D, Neurauter CG, Suganthan R, Sejersted Y, Hildrestrand GA, Bjørås M, Luna L (2013) 
Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress. Biochim Biophys Acta. 2013 May;1833(5):1157-64. doi: 10.1016/j.bbamcr.2012.12.024. Epub 2013 Jan 7. 

Cornez I, Joel M, Taskén K, Langmoen IA, Glover JC, Berge T (2013) 
EGF signalling and rapamycin-mediated mTOR inhibition in glioblastoma multiforme evaluated by phospho-specific flow cytometry.
J Neurooncol. 2013 Mar;112(1):49-57. doi: 10.1007/s11060-012-1035-9. Epub 2013 Jan 9. 

Jobert L, Skjeldam HK, Dalhus B, Galashevskaya A, Vågbø CB, Bjørås M, Nilsen H (2013) 
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control. Mol Cell. 2013 Jan 24;49(2):339-45. doi: 10.1016/j.molcel.2012.11.010. Epub 2012 Dec 13. 

Dalhus B, Nilsen L, Korvald H, Huffman J, Forstrøm RJ, McMurray CT, Alseth I, Tainer JA, Bjørås M (2013) Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2. 
Structure. 2013 Jan 8;21(1):154-66. doi: 10.1016/j.str.2012.11.004. Epub 2012 Dec 13. 

Midttun Ø, Kvalheim G, Ueland PM (2013) 
High-throughput, low-volume, multianalyte quantification of plasma metabolites related to one-carbon metabolism using HPLC-MS/MS. 
Anal Bioanal Chem. 2013 Feb;405(6):2009-17. doi: 10.1007/s00216-012-6602-6. Epub 2012 Dec 13. 

Delbarre E, Ivanauskiene K, Küntziger T, Collas P (2013) 
DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin. 
Genome Res. 2013 Mar;23(3):440-51. doi: 10.1101/gr.142703.112. Epub 2012 Dec 5. 

Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C (2013) 
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. 
Mol Cell. 2013 Jan 10;49(1):18-29. doi: 10.1016/j.molcel.2012.10.015. Epub 2012 Nov 21. 

Ohnstad HO, Castro R, Sun J, Heintz KM, Vassilev LT, Bjerkehagen B, Kresse SH, Meza-Zepeda LA, Myklebost O (2013) 
Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma. 
Cancer. 2013 Mar 1;119(5):1013-22. doi: 10.1002/cncr.27837. Epub 2012 Nov 16. 

Boulland JL, Mastrangelopoulou M, Boquest AC, Jakobsen R, Noer A, Glover JC, Collas P (2013) 
Epigenetic regulation of nestin expression during neurogenic differentiation of adipose tissue stem cells. Stem Cells Dev. 2013 Apr 1;22(7):1042-52. doi: 10.1089/scd.2012.0560. Epub 2012 Dec 21. 

Jung AY, Botma A, Lute C, Blom HJ, Ueland PM, Kvalheim G, Midttun Ø, Nagengast F, Steegenga W, Kampman E (2013) 
Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas. 
Mol Nutr Food Res. 2013 Apr;57(4):698-708. doi: 10.1002/mnfr.201200069. Epub 2012 Nov 7. 

Eide N, Hoifødt HK, Nesland JM, Faye RS, Qvale GA, Faber RT, Jebsen P, Kvalheim G, Fodstad O (2013) Disseminated tumour cells in bone marrow of patients with uveal melanoma. 
Acta Ophthalmol. 2013 Jun;91(4):343-8. doi: 10.1111/j.1755-3768.2012.02449.x. Epub 2012 May 25. 

Haug K, Azqueta A, Johnsen-Soriano S, Shahdadfar A, Drolsum LK, Moe MC, Røger MT, Romero FJ, Collins AR, Nicolaissen B (2013) 
Donor cornea transfer from Optisol GS to organ culture storage: a two-step procedure to increase donor tissue lifespan. Acta Ophthalmol. 2013 May;91(3):219-25. doi: 10.1111/j.1755-3768.2012.02390.x. Epub 2012 Mar 16.